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“Feel Good” Brain Chemical Dopamine Can Be Willfully Controlled

Neuroscientists show that mice can learn to manipulate random dopamine impulses for reward.

From the thrill of hearing an ice cream truck approaching to the spikes of pleasure while sipping a fine wine, the neurological messenger known as dopamine has been popularly described as the brain’s “feel good” chemical related to reward and pleasure.

A ubiquitous neurotransmitter that carries signals between brain cells, dopamine, among its many functions, is involved in multiple aspects of cognitive processing. The chemical messenger has been extensively studied from the perspective of external cues, or “deterministic” signals. Instead, University of California San Diego researchers recently set out to investigate less understood aspects related to spontaneous impulses of dopamine. Their results, published on July 23, 2021, in the journal Current Biology, have shown that mice can willfully manipulate these random dopamine pulses.

Spontaneous Dopamine Pulses

UC San Diego researchers and their colleagues have discovered that spontaneous impulses of dopamine, the neurological messenger known as the brain’s “feel good” chemical, occur in the brains of mice. Credit: Julia Kuhl

Rather than only occurring when presented with pleasurable, or reward-based expectations, UC San Diego graduate student Conrad Foo led research that found that the neocortex in mice is flooded with unpredictable impulses of dopamine that occur approximately once per minute.

Working with colleagues at UC San Diego (Department of Physics and Section of Neurobiology) and the Icahn School of Medicine at Mount Sinai in New York, Foo investigated whether mice are in fact aware that these impulses–documented in the lab through molecular and optical imaging techniques–are actually occurring. The researchers devised a feedback scheme in which mice on a treadmill received a reward if they showed they were able to control the impromptu dopamine signals. Not only were mice aware of these dopamine impulses, the data revealed, but the results confirmed that they learned to anticipate and volitionally act upon a portion of them.

Spontaneous Impulses of Dopamine in Neocortex

UC graduate student Conrad Foo and his colleagues found that spontaneous impulses of dopamine occur in the cortex of mice at a rate of approximately 0.01 per second. Using a reinforcement learning paradigm based on rewards, mice learned to volitionally modulate their spontaneous impulses. Credit: Julia Kuhl

“Critically, mice learned to reliably elicit (dopamine) impulses prior to receiving a reward,” the researchers note in the paper. “These effects reversed when the reward was removed. We posit that spontaneous dopamine impulses may serve as a salient cognitive event in behavioral planning.”

The researchers say the study opens a new dimension in the study of dopamine and brain dynamics. They now intend to extend this research to explore if and how unpredictable dopamine events drive foraging, which is an essential aspect of seeking sustenance, finding a mate, and as a social behavior in colonizing new home bases.

“We further conjecture that an animal’s sense of spontaneous dopamine impulses may motivate it to search and forage in the absence of known reward-predictive stimuli,” the researchers noted.

In their efforts to control dopamine, the researchers clarified that dopamine appears to invigorate, rather than initiate, motor behavior.

“This started as a serendipitous finding by a talented, and curious, graduate student with intellectual support from a wonderful group of colleagues,” said study senior co-author David Kleinfeld, a professor in the Department of Physics (Division of Physical Sciences) and Section of Neurobiology (Division of Biological Sciences). “As an unanticipated result, we spent many long days expanding on the original study and of course performing control experiments to verify the claims. These led to the current conclusions.”

Reference: “Reinforcement learning links spontaneous cortical dopamine impulses to reward” by Conrad Foo, Adrian Lozada, Johnatan Aljadeff, Yulong Li, Jing W. Wang, Paul A. Slesinger and David Kleinfeld, 23 July 2021, Current Biology.
DOI: 10.1016/j.cub.2021.06.069

The full authors list of the paper includes: Conrad Foo, Adrian Lozada, Johnatan Aljadeff, Yulong Li, Jing W. Wang, Paul A. Slesinger and David Kleinfeld.

Funding: BRAIN Initiative, National Institutes of Health



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